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boulardii (1 10 9 CFU/day) was fed to a chronic renal failure model (nephrectomized rats) for 16-weeks trial and reduced blood urea nitrogen (BUN) levels and extended life were observed (Ranganathan et al., 2005)

However, glucagon has potent effects on hepatic glucose, lipid and amino acid metabolism

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Consistency over 8 to 12 weeks is typically more impactful than short-term high dosing